|
|
|
The Axxam Gene Expression group offers both single gene - The GeneTrawler® - and global genome expression analysis utilizing our outstanding collection of normal and diseased human tissues. These tools allow the identification and characterization of prospective pharmaceutical targets from the genomic pool by studying expression patterns of druggable gene products.
By partnering with Axxam for your gene expression requirements, you benefit not only from our highly-automated and rapid high-throughput techniques but also the utilization of established standards for expression profiling, knowledge integration and flexible experimental design that allow for tailor-made solutions and direct communication with the scientist dedicated to each project.
The GeneTrawler® is an enabling tool for characterization based on single gene expression profiling developed to prioritize targets in the early phases of drug discovery.
The GeneTrawler® profile of your gene of interest is a detailed picture of its expression in the human (and/or rat) body.
Your targets characterization utilizing the GeneTrawler® creates a greater understanding
of it by:
- mapping its expression throughout the entire human (rat) body and organ systems
- allowing the extraction of the maximum value from every prospective or known target, uncovering alternative therapeutic options
- predicting the impact of possible drug side effects.
The GeneTrawler® also allows the identification of new targets for designated therapeutic indications.
Our scientists have established a high-throughput system for the quantitative analysis of gene expression. This allows the specific and quantitative determination of any gene transcript, including splice variants, through hundreds of samples in a short time.
For more information about The GeneTrawler® please contact us.
Global gene expression analysis is performed using microassay technology combined with advanced informatics, bioinformatics and LIMS for microarray data analysis and annotation plus pathway analysis. Microarray experiments and results are subject to stringent quality control procedures and particular care is taken in data processing as critical steps that lead to the success of each project.
With this approach, Axxam scientists have generated a database of non-diseased human transcriptomes from 20 different normal tissue types and conduct projects in a number of therapeutic areas using differential expression analysis:
- in pathological versus normal human tissues
- in tissues from diseased animal models
- in samples from in vitro systems.
Please contact us for licensing opportunities of human transcriptomes datasets for target identification projects. |
|
|
|
|
|
|
