As part of our commitment to help our customers to rapidly identify promising hits, we offer high-throughput screening of our compound collection. We use our library to screen your target in your chosen assay format on Axxam’s automated high-throughput screening stations.
For the creation and assembly of AXXDIV, millions of commercially available compounds were filtered to select a set of compounds that serve as an excellent starting point for the identification of small molecule hits from a wide variety of target types. Particular attention was given to the choice of structurally diverse compounds, in order to represent a large chemical space. We also selected compounds with predicted favorable physicochemical and pharmacokinetic (ADMET) characteristics, to minimize the number of compounds in the library with undesirable properties and produce hits with a high chance of progressing into suitable leads for optimization.
More than 80% of our compound collection has zero violations of the Lipinski 'Rule of 5' for oral drug-like properties, and more than 70% has zero violations of the Oprea criteria for lead-like properties.
Using AXXDIV means:
- Exposing your target of choice to more than 130,000 carefully selected small molecules
- Taking advantage of Axxam’s expertise in high throughput screening to identify meaningful hits Obtaining the structures for all of your selected hits
- Availability of compounds from commercial suppliers
- Consistent automation
